Buried in sand in the warm waters of the Bay of Bengal, a predator waits. As a fish darts past, a tiny harpoon tipped with deadly venom flashes by and buries itself in the fish. The, predator, a marine cone snail of the genus Conus glides towards the paralysed, weakly twitching fish and engulfs it. It’s all over in a matter of seconds. The potent neurotoxic venoms of Conus snails, called conotoxins, are hot topics for research since they have immense potential as pain relief agents or analgesics (think very strong, but non-addictive morphine). Researchers from the Molecular Biophysics Unit at the Indian Institute of Science, Bangalore, have added their mite to this fascinating field. They have figured out the 3-dimensional structure of a conotoxin named Mo3964 from the venom of the cone snail Conus monile.