What is common between albumin, gelatin and casein? They are all proteins! And not just that, they are proteins used for the synthesis of nanoparticles. Proteins are large biomolecules that are composed of long chains of amino acids. The chemical groups that the amino acid are composed of lead to the protein having polar (water soluble) and nonpolar (water insoluble) regions. Hence when introduced into water, proteins tend to bury their nonpolar region by folding into different 3D shapes. Desolvation is a common process to construct nanoparticles in which this balance of electrostatic and hydrophobic interactions is disturbed, causing a protein to precipitate i.e. damage its 3D structure. But when done in controlled experimental conditions, due to chemical cross linking, desolvation process leads to the formation of homogenous aggregates. In a recent study researchers from Centre for Cellular and Molecular Biology, Hyderabad have studied, in detail, the desolvation process of gelatin, with particular focus on the role of pH and desolvating agent in nanoparticle synthesis. This research provides insight into the Gelatin nanoparticle assembly and could improve the process of drug delivery through nanoparticles.