Chemogenetics is a technique that uses chemicals to understand how neurons are activated. It manipulates genes to place the neurons under the control of special receptors called DREADDS. Short for Designer Receptors Activated by Designer Drugs, these receptors only bind to an inert chemical called Clozapine-N-Oxide (CNO). In a recent study, researchers from the Tata Institute of Fundamental Research (TIFR), Mumbai, and Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR), Bengaluru, point out specific flaws in this technique.