The nucleus of the cell holds our genetic material and is a vital part of our cell. Apart from what they carry, how they look also plays a crucial role in diagnosing many diseases. In a recent study, researchers at the Indian Institute of Science (IISc), Bengaluru, have developed a mechanical model to quantify the shape of the nucleus and predict the biochemistry within a cell. They have used this model to show how Hepatitis C virus changes the nuclear mechanics of cells affected by it. This study is published in the Biophysical Journal.