Research Matters

Autophagy, or self-eating, is a process where cells in our body devour some of the cell components to replenish their nutrient supply during severe shortage.  This process, though sounds gruesome, is essential for our survival and any defect in this mechanism could lead to neurodegenerative disorders like Parkinson’s disease. Several research, inspired by Nobel Laureate Prof. Yoshinori Ohsumi’s work on autophagy, has now uncovered new dimensions on our understanding of how cells function.

Escherichia coli, a poster boy for microbiology research and the notorious bacteria that causes stomach infections, might soon be an unusual source of inspiration for us, humans, for learning how to handle stress! A new study by scientists at the Indian Institute of Science, Education and Research (IISER)  Pune, has revealed, for the first time, that E. coli cells become more sturdy and fit when exposed to unpredictably fluctuating environments containing high levels of salts or chemicals, or having extreme pH values.  Led by Prof. Sutirth Dey, the study aims to investigate the evolution of fitness and the costs incurred by the bacteria in this process.

How do stars and star clusters influence their neighbourhood? How does the birth of stars affect their neighbours? let us start with the birth of a star. It begins with gasses, mostly hydrogen, accumulating under gravity until it gets hot and dense enough to start nuclear fusion, where the lighter Hydrogen atoms merge to form heavier helium atoms, with an enormous outburst of energy. This energy moves in the form of a shockwave, pushing all the excess gas away from the newborn star. For a million years after its birth, high energy radiation from the star continues to push the surrounding gas away. From here the picture gets a little murky as we hadn’t quite understood what happened around a star or a cluster of stars, after the million year mark. Now a new study by researchers from Raman Research Institute (RRI), the Indian Institute of Science (IISc) and P.N Lebedev Physical Institute, Moscow, Russia could throw more light on this issue. They have successfully developed a model to simulate the interaction of a star cluster with its surroundings. The model was then tested for accuracy by comparing it with observations from Tarantula Nebula, a nearby star cluster, where the observations matched closely to the predictions made by the model. Maybe now we can better understand the processes that guide the formation of stars, nebulae and galaxies!  

The Internet has revolutionised our way of life, enabling things that were hard to imagine earlier. With the Internet, one can work sitting at home, doctors can treat patients anywhere in the world, and with the advent of smartphones, simple activities like commuting has a whole new meaning. Social media platforms like Facebook, Twitter and YouTube have redefined communication and made reaching out to a large number of people very easy. Any of us can be an ‘influencer’ with the potential to be heard by millions of people.

If you have read Malcolm Gladwell’s ‘Outliers,' then you might be well acquainted with the ‘10,000-hour rule’, which states that to master a new skill, such as playing the piano or knitting, one needs 10,000 hours of practice to become world-class. This long practice, studies show, facilitates ‘motor learning’ - a set of complex processes that occur in the brain in response to practice or experience of a certain skill, resulting in changes in the central nervous system.

If you have ever visited the Jawaharlal Nehru Planetarium (JNP) in Bengaluru, you are sure to be mesmerized by the art of story telling in the recorded videos played during the shows and the cartoons on display. If there is one person that has to be credited to introducing this uniqueness to the planetarium, it is definitely Prof. C V Vishveshwara, famously called the ‘black hole man of India’.

The 3rd of March every year was declared World Wildlife Day by the United Nations General Assembly to mark the signing of the landmark Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) in 1973. Aimed at celebrating and raising awareness of the world’s wild animals and plants, the day is a chance for us to think about the major threats to wildlife including habitat change, over-exploitation and illicit trafficking.

In 1948, celebrated physicist and Nobel laureate, Richard Feynman introduced what came to be called Feynman diagrams. These were a pictorial representation of mathematical equations and served as a powerful tool in understanding and visualizing complex interactions between sub-atomic particles like protons and electrons. But this simplistic tool could not handle complex problems, where particles underwent many interactions, but instead produced incomprehensible and confounding answers, like infinities.

Technology has revolutionised medicine in the past century. We now have imaging methodologies like X-rays, Computed Tomography (CT) scans and Magnetic Resonance Imaging (MRI) allowing us a look inside the body without cutting it open. Nanotechnology seems poised to write the next chapter of this revolution, with various applications in biomedical imaging, diagnosis and effective treatment of diseases. In yet another advancement in this direction, an interdisciplinary team of scientists from Materials Engineering Department and Department of Microbiology and Cell Biology at the Indian Institute of Science (IISc), Bangalore, have synthesised iron nanoparticles without any oxide cover that could be used to enhance the sensitivity of MRI by producing images with better contrast. They have also demonstrated the potential application of this research in the targeted delivery of medicines and other biological molecules to specific organs in the body.

This year’s National Science Day, celebrated to commemorate the discovery of Dr. C V Raman’s ‘Raman Effect’, is themed around ‘Science and Technology for Specially Abled Persons’. One billion people, or 15% of the world’s population, experience some form of disability today, and the prevalence of disability is highest in developing countries like India. A report by World Bank estimates that about 110-190 million of them experience significant disabilities.  ‘Persons with disabilities’ or PwDs include those who have long-term physical, mental, intellectual or sensory impairments which may hinder their full and effective participation in the society.