Scientists at Indian Institute of Technology Indore, Indore have developed L-lyso—a novel water soluble, fluorescent dye which can permeate the membranes of lysosomes, marking them for future tracking and imaging.
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Cells are the building blocks of life and have witnessed many exciting phases of evolution. Over this period, since the beginning of life several million years ago, the functionalities of the cell and its organelles have become sophisticated. Cells have also evolved smarter ways to address common challenges and one of them is the acidification of the enzymes found inside cells. While this acidic environment serves many well known functions, a new study shares an interesting hypothesis on the reason behind the acidic pH -- detecting leaks in the cell. Since synthesis of enzymes is an expensive process, the study argues that cells use the acidic medium to detect possible leaks, thus saving energy in the process.