Our genetic material is a big molecule of DNA or deoxyribonucleic acid, whose structure is a double-stranded wound-up helix. It contains specific instructions that run a living cell, and these instructions are written on the strands. When cells divide, the DNA replicates too. In this process, the contents of the strands are read and copied carefully by unwinding the strands. But that's not as simple!

A collaborative study by researchers from Punjab University, Indian Institute of Technology (IIT) Delhi, Banasthali University, TERI University and the Jawaharlal Nehru University has identified how a particular gene in Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), mutates to avoid the action of antibiotics.

Scientists from the Central University of Gujarat (CUG), Gandhinagar, use computers to design the most efficient drug against TB. They apply pharmacophore modelling approach to understand the interactions between proteins found in Mycobacterium tuberculosis (Mtb) and the compounds which can suppress the bacteria. 

The whole world is struggling with the problem of antibiotic resistance developed by disease causing organisms. The epidemic of Tuberculosis especially plagues countries like India. In their recent research scientists from the Central University, Punjab have identified a new target drug to beat the bacteria’s defense against antibiotics.

A new study at IISc looks to uncover the secret behind the development of drug resistance in TB causing bacteria by testing the efficacy of various commonly available antibiotics. The researchers have found that a combination of commonly available antibiotics along with Augmentin, fights the development of resistance among TB bacteria. This study might throw light on developing new class of drugs that can help contain the spread of deadly tuberculosis, claim the researchers.

Though our fight against tuberculosis has a long history, we have not been able to wipe off this bacterial infection from the face of the planet. Even to this day, there are numerous studies all over the world that are trying to find the ‘best’ drug against this killer disease. In a new approach to fight tuberculosis, a recent study has now shone some light on how our body fights Mycobacterium, the causative bacteria of TB. Understanding this mechanism, the researchers say, could open up new vaccines and drugs against TB and help us win the seemingly never ending battle. 

Tuberculosis or TB is a disease known to mankind since our existence on Earth. In spite of that, our fight against this deadly disease still continues. A major breakthrough in this fight is the identification of Mycobacterium tuberculosis, the bacteria that causes TB, in the 19th century. World Tuberculosis Day is celebrated commemorating that significant day, when Robert Koch discovered this deadly bacteria that has now become stronger than ever, and standing tall against all odds in this fight. Will we ever succeed? Only time can tell.