Chemogenetics is a technique that uses chemicals to understand how neurons are activated. It manipulates genes to place the neurons under the control of special receptors called DREADDS. Short for Designer Receptors Activated by Designer Drugs, these receptors only bind to an inert chemical called Clozapine-N-Oxide (CNO). In a recent study, researchers from the Tata Institute of Fundamental Research (TIFR), Mumbai, and Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR), Bengaluru, point out specific flaws in this technique.

An international study, led by researchers from the USA, which also included researchers from India, have designed a point-of-care testing approach for individuals suffering from TB. The study, published in the journal Science Translational Medicine and supported in part by the Bill and Melinda Gates Foundation, proposes a rapid, cost-effective, and readily accessible triage test kit that can be used at the site of patient care.

Researchers from the Indian Institute of Science (IISc), Bengaluru study how a protein called lysozyme, an integral component of our immune system, causes persistent nerve pain during nerve injury.

In a recent study, Dr Sachdev and an international team of researchers have shown that India’s mortality rate due to severe acute malnutrition is a fraction of the WHO estimates. This study is published in the journal PLOS Medicine.

As Newton’s famous quote, “standing on the shoulders of giants”, this year, science has made considerable advances, building on many feats achieved in the past years. New discoveries, insights and inventions in the areas of astronomy, biology, medicine, paleontology and physics marked the year. Here is a selected pick of ten such breakthroughs in science witnessed in 2019.

While looking forward to 2020, the editorial team at Research Matters looks back on some of the interesting stories that we published during 2019. There were many interesting ones ranging from the first photograph of a black hole to air pollution in Delhi to using vibrations for painless injections. Here is a list to highlight India's year in science during 2019. This is in no way ranked and the order is just incidental.

2019 was an exciting year for science as ever. We have collated the top ten stories that was popular on Research Matters in 2019. These were the ones that garnered most views because of readers like you. We would like to thank you for patronage and look forward to your support in the years to come.

In a study published in the journal The Lancet Oncology, the researchers collected and analyzed data from various published reports such as the Global WHO FCTC Implementation Progress Reports of 2012, 2014, 2016, 2018, WHO reports on global tobacco epidemic 2013, 2015 and 2017, Global Tobacco Surveillance System Data and the WHO-NCI Monograph. They examined the prevalence, trends and policy progress in smokeless tobacco control on the lines of the WHO FCTC guidelines.

Pune researchers take a molecular modelling approach to identify drug targets for the deadly Nipah virus.

Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV). The virus spreads through blood-to-blood contact, and is usually associated with the use of intravenous drug use, blood donations and other unhygienic use of medical equipment leading to exchange of blood. Once infected, a patient can go years without facing severe symptoms, like liver failure and cirrhosis, only to feel it’s accumulated effects after a long period.